反应详情

A microwave vial was charged with copper (I) cyanide (1.089 g, 12.16 mmol), 2,3-dibromo-5-chloropyridine (3 g, 11.06 mmol), and propionitrile (15 mL). The vial was capped and irradiated in a microwave reactor at 150° C. for 2.5 hours. The solution was concentrated, diluted with DCM (25 mL), and filtered. The filtrate was concentrated, and the residue was purified by silica gel chromatography, eluting with 0-30% EtOAc in heptanes, to afford the title compound (2 g, 9.20 mmol). MS m/z=219 (M+H)+.

1. customThe vial was capped
2. customirradiated in a microwave reactor at 150° C. for 2.5 hours
3. concentrationThe solution was concentrated
4. additiondiluted with DCM (25 mL)
5. filtrationfiltered
6. concentrationThe filtrate was concentrated
7. customthe residue was purified by silica gel chromatography
8. washeluting with 0-30% EtOAc in heptanes