Methanol → 5-Chloro-2-methoxypyrido[3,4-b]pyrazine

HRID 1526551ノート

反応式

HRID 1526551 の反応式
Cl[C:2]1[N:3]=[C:4]2[CH:11]=[CH:10][N:9]=[C:8]([Cl:12])[C:5]2=[N:6][CH:7]=1.[CH3:13][O-:14].[Na+].CO>CN(C)C=O.O>[Cl:12][C:8]1[C:5]2=[N:6][CH:7]=[C:2]([O:14][CH3:13])[N:3]=[C:4]2[CH:11]=[CH:10][N:9]=1

参加物

6

反応物 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 867157432,5-Dichloropyrido[3,4-b]pyrazine

生成物 1

HCID 867157445-Chloro-2-methoxypyrido[3,4-b]pyrazine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 2,5-dichloropyrido[3,4-b]pyrazine (580 mg, 2.90 mmol) in N,N-dimethylformamide (10 mL) was added a 0.5-M solution of sodium methoxide in methanol (6.09 mL, 3.04 mmol), and the reaction was stirred at RT for 5 minutes. The solution was diluted with water and extracted with ethyl acetate. The organic layer was dried with sodium sulfate, filtered and concentrated to afford the title compound (550 mg, 2.81 mmol). MS m/z=196 (M+H)+.

後処理

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer was dried with sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-e84eb989f390477eb6f76d8a8c10acd3
出典データセット
uspto-grants-2015_07
特許番号
US09085576B2

反応ノート

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