反应详情

温度

90 °C

Ammonia gas was bubbled through a solution of 2,6-difluoro-4-methoxybenzonitrile (1.0 g, 5.91 mmol) in dimethylsulfoxide (11.83 mL) for 10 minutes. The reaction was then sealed and stirred at 90° C. for 24 hours. The reaction mixture was cooled to RT and concentrated in vacuo to afford a tan residue. The residue was triturated with water, collected be vacuum filtration, and dried in vacuo to afford the title intermediate (0.9 g, 5.42 mmol) as a white solid. LC/MS (ESI+) m/z=167 (M+H)+.

1. customThe reaction was then sealed
2. temperatureThe reaction mixture was cooled to RT
3. concentrationconcentrated in vacuo
4. customto afford a tan residue
5. customThe residue was triturated with water
6. customcollected
7. filtrationvacuum filtration
8. customdried in vacuo