Methyl 5-hydroxypyridine-2-carboxylate → HCID 90389344, compound

HRID 1526591Notes

Reaction equation

HRID 1526591 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([O:10]C)=[O:9])=[N:6][CH:7]=1.[O:12]1[CH:16]=[CH:15][N:14]=[C:13]1[CH2:17]O>>[O:12]1[CH:16]=[CH:15][N:14]=[C:13]1[CH2:17][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:10])=[O:9])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 4715126Methyl 5-hydroxypyridine-2-carboxylateHCID 14786610(1,3-Oxazol-2-yl)methanol

Product 1

HCID 90389344HCID 90389344, compound

Procedure

The title compound was synthesized analogously according to Method S starting from methyl 5-hydroxypicolinate (Molbridge) and oxazol-2-ylmethanol (AstaTech). MS m/z=237.9 [M+H]+. Calculated for C9H7N3O3S. 1H NMR (400 MHz, DMSO-d6) δ ppm 5.59 (s, 2H) 7.86 (d, J=1.96 Hz, 1H) 8.45 (d, J=1.17 Hz, 1H) 8.83 (d, J=1.37 Hz, 1H) 9.14 (d, J=1.96 Hz, 1H)

Sources & evidence

ORD record
ord-b932b2ef8c294635bdc490c008ec31cf
Source dataset
uspto-grants-2015_07
Patent number
US09085576B2

Reaction notes

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