Ethyl bromopyruvate → Ethyl 2-(difluoromethyl)thiazole-4-carboxylate

HRID 1526603Notes

Reaction equation

HRID 1526603 reaction equation
[F:1][CH:2]([F:6])[C:3](=[S:5])[NH2:4].Br[CH2:8][C:9](=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11]>CCO>[F:1][CH:2]([F:6])[C:3]1[S:5][CH:8]=[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:4]=1

Participants

4

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 221411002,2-Difluoroethanethioamide

Product 1

HCID 89690438Ethyl 2-(difluoromethyl)thiazole-4-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of 2,2-difluoroethanethioamide (1.023 g, 9.21 mmol) and ethyl bromopyruvate (1.150 mL, 9.21 mmol) in EtOH (20 mL) was heated to 50° C. for 2 h.

Sources & evidence

ORD record
ord-edcd9721cc3c4bfbbf3c551fd25dcd55
Source dataset
uspto-grants-2015_07
Patent number
US09085576B2

Reaction notes

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