HCID 86675419, compound → HCID 12113982, compound

HRID 1526667Notes

Reaction equation

HRID 1526667 reaction equation
C[O:2][CH:3](OC)[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]2[C:33]3[C@@H:17]([CH2:18][CH2:19][C@:20]4(O)[C:32]=3[CH2:31][CH2:30][C:22]3(OCC(C)(C)C[O:23]3)[CH2:21]4)[C@H:16]3[C@@:12]([CH3:43])([C@@:13]([C:36]([F:42])([F:41])[C:37]([F:40])([F:39])[F:38])([OH:35])[CH2:14][CH2:15]3)[CH2:11]2)=[CH:6][CH:5]=1>C(O)(=O)C>[OH:35][C@@:13]1([C:36]([F:41])([F:42])[C:37]([F:38])([F:39])[F:40])[CH2:14][CH2:15][C@H:16]2[C@H:17]3[C:33]([C@@H:10]([C:7]4[CH:6]=[CH:5][C:4]([CH:3]=[O:2])=[CH:9][CH:8]=4)[CH2:11][C@:12]12[CH3:43])=[C:32]1[C:20](=[CH:21][C:22](=[O:23])[CH2:30][CH2:31]1)[CH2:19][CH2:18]3

Participants

3

Reactant 1

HCID 86675419HCID 86675419, compound

Product 1

HCID 12113982HCID 12113982, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
30 °C

Procedure

3.5 g of the compound described under 1b) were dissolved in 55 ml of 70% strength acetic acid. The mixture was after-stirred for 16 hours at 30° C. The reaction mixture was then poured onto water and after-stirred for a further 5 hours. It was then filtered. The residue was washed with water, dried and purified by chromatography over silica gel. This gave 2.2 g of the title compound.

Workup

  1. additionThe reaction mixture was then poured onto water
  2. stirringafter-stirred for a further 5 hours
  3. filtrationIt was then filtered
  4. washThe residue was washed with water
  5. customdried
  6. custompurified by chromatography over silica gel

Sources & evidence

ORD record
ord-7249b4bacd404f86b5a085c580139738
Source dataset
uspto-grants-2015_07
Patent number
US09085603B2

Reaction notes

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