HCID 131733180, compound → Deldeprevir

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Reaction Steps

The solubility of ACH-0142684 sodium salt was determined at room temperature using the following procedure. The input material (˜10 mg) was weighed into each of 12 vials, followed by addition of a solvent in multiple aliquots between 50μL to 10-mL at room temperature. Samples were visually inspected for complete dissolution after each solvent addition. The solubility of crystalline ACH-0142684 sodium salt is summarized in TABLE 1, which provides a solubility assessment of amorphous API in 12 solvents. The solubility of API-0142684 in water after temperature cycling between 40° C. and 5° C. for 2 days is ˜50 mg/ml.

Provenance & Evidence