反应详情

A solution of potassium hydroxide (8.60 g, 153 mmol) in water (100 mL) was added to a solution of the above ester (9.20 g, 30.6 mmol) in methanol (100 mL) and the resulting mixture was heated at 60 C for 2 days. The mixture was cooled to room temperature; then it was washed with hexanes (2×70 mL) and concentrated in vacuo. Concentrated hydrochloric acid (32%, 20 mL, 0.65 mol) was added dropwise and the mixture was extracted with ethyl acetate (2×150 mL). The combined organic layers were dried over anhydrous magnesium sulfate and evaporated to dryness to yield 14-hydroxy-tetradecanoic acid as white solid.

1. temperaturethe resulting mixture was heated at 60 C for 2 days
2. washthen it was washed with hexanes (2×70 mL)
3. concentrationconcentrated in vacuo
4. extractionthe mixture was extracted with ethyl acetate (2×150 mL)
5. dry with materialThe combined organic layers were dried over anhydrous magnesium sulfate
6. customevaporated to dryness