反应详情

p-Toluenesulfonic acid monohydrate (0.28 g, 1.45 mmol) was added to a solution of the above 14-hydroxy-tetradecanoic acid (7.10 g, 29.1 mmol) in methanol (150 mL) and the resulting solution was stirred at room temperature for 3 days. Methanol was removed under reduced pressure; the residue was dissolved in ethyl acetate (170 mL); washed with 5% aqueous solution of sodium carbonate (3×50 mL) and brine (25 mL); dried over anhydrous magnesium sulfate and evaporated in vacuo to give methyl 14-hydroxy-tetradecanoate as white solid.

1. customMethanol was removed under reduced pressure
2. dissolutionthe residue was dissolved in ethyl acetate (170 mL)
3. washwashed with 5% aqueous solution of sodium carbonate (3×50 mL) and brine (25 mL)
4. dry with materialdried over anhydrous magnesium sulfate
5. customevaporated in vacuo