Sodium Hydroxide → HCID 72950364, compound

Participants

Reaction Steps

A suspension of ethyl 3-amino-3-(3-bromo-5-tert-butylphenyl)-propionate hydrochloride (125 g, 0.38 mol) in water (500 mL) was basified with 2.5 N NaOH (pH ˜12) by drop-wise addition to give a creamy oily residue. The pH of the aqueous layer was adjusted to pH=8.2 by the addition of 50 mM KH2PO4 solution. Amano lipase PS (75 g) was added to above reaction mixture and the reaction mixture was stirred overnight at room temperature. The reaction mixture was filtered and the solid was washed with ethyl acetate to give a colorless solid of the resolved (S)-acid (37 g).

Provenance & Evidence