反应详情

Method C. Reaction of benzoate 22 (97 mg, 0.23 mmol) and 6 M HCl (5 mL) gave acid 23 (85 mg, 89%) as a white solid: mp (H2O) 220-222° C.; 1H NMR δ 13.15 (br s, 1 H, CO2H), 8.02 (dd, J=8.7, 1.9Hz, 2 H, H-2, H-6), 7.88 (ddd, J=8.7, 1.9, 1.5Hz, 2 H, H-3, H-5), 7.70 (ddd, J=8.6, 2.0, 1.9Hz, 2 H, H-2′, H-6′), 7.63 (ddd, J=8.6, 2.0, 1.9Hz, 2 H, H-3′, H-5′), 4.64 (s, 2 H, CH2SO2), 2.14 (s, 3 H, CH3), 1.29 [s, 9 H, C(CH3)3]; MS m/z 415.5 (MH+, 100%). Anal. calcd for C22H23NO5SH2O: C, 61.24; H, 5.84; N, 3.25. Found: C, 61.32; H, 5.50; N, 3.14%.