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Sodium Hydroxide → 4-[4-(Hydroxymethyl)-5-methyl-1,3-oxazol-2-yl]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Methyl 4-(4-(chloromethyl)-5-methyloxazol-2-yl)benzoate | HCID 23076573 | — |
| 生成物 | 4-[4-(Hydroxymethyl)-5-methyl-1,3-oxazol-2-yl]benzoic acid | HCID 68278425 | 72% |
反応手順
Method D. Reaction of chloride 2 (500 mg, 1.88 mmol) and aqueous NaOH (2 M, 10 mL, 20 mmol) gave acid 55 (313 mg, 72%) as a cream solid: mp (EtOAc/MeOH) 240-242° C.; 1H NMR δ 13.18 (br s, 1H, CO2H), 8.00-8.06 (m, 4 H, H-2, H-3, H-5, H-6), 5.11 (br s, 1 H, OH), 2.41 (s, 3 H, CH3); MS m/z 234.5 (WE, 100%); HRMS calcd for C12H12NO4: 234.0761. Found: 234.0760.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09085570B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-0aa403afea9d497fbbf8561a0b3bec33 |
| 出典メモ | uspto-grants-2015_07 |