HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1527082Generated: November 2, 2026
Trifluoroacetic acid → 1-(3-methoxybutan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
https://huagongshe.com/reaction/1527082
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl 1-(3-methoxybutan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate | HCID 89740318 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(3-methoxybutan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid | HCID 117778607 | — |
Reaction Steps
To the pre-cooled solution of tert-butyl 1-(3-methoxybutan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (3.0 g, 9.42 mmol) in CH2Cl2 (20 mL) was added trifluoroacetic acid (20 mL) dropwise. The solution was stirred at 27° C. for 1.5 hours. The solvent was removed under vacuum at 27° C. The residue was used for next step without purified. LCMS (M+H+) m/z: calcd 263.30. found 262.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09085583B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-88b151a5c50d4f99b617d7ba0038bdef |
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| Source note | uspto-grants-2015_07 |
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