HCID 10703244, compound → HCID 12915443, compound

HRID 1527120Notes

Reaction equation

HRID 1527120 reaction equation
[CH:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2)=[CH2:2]>[Pd].CO>[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2]

Participants

4

Reactant 1

HCID 10703244HCID 10703244, compound

Product 1

HCID 12915443HCID 12915443, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Methyl 2-vinyl-1H-indole-3-carboxylate (80 mg, 0.4 mmol) and 10% palladium on charcoal (100 mg) in methanol (30 mL) were stirred under hydrogen 0.2 MPa at room temperature for 15 hours. The mixture was filterated the solid and concentrated in vacuum to obtain methyl 2-ethyl-1H-indole-3-carboxylate as a white solid (79 mg, 99%) LRMS (M+H+) m/z: calcd 203.1 found 203.

Workup

  1. concentrationconcentrated in vacuum

Sources & evidence

ORD record
ord-de0a0dd18c3c4257b0c83926056f00bf
Source dataset
uspto-grants-2015_07
Patent number
US09085583B2

Reaction notes

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