HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1527145Generated: November 4, 2026
Ethyl Acrylate → Ethyl 3-(pyridin-2-ylamino)propanoate
https://huagongshe.com/reaction/1527145
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acrylate | HCID 8821 | — |
| Reactant | 2-Aminopyridine | HCID 10439 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Ethyl 3-(pyridin-2-ylamino)propanoate | HCID 11984503 | 87.4% |
Reaction Steps
200 g (2.12 mol) of 2-aminopyridine and 346 mL (3.19 mol) of ethyl acrylate were dissolved in 53 mL of acetic acid. The mixture was heated to 88° C. and stirred overnight at this temperature. Solvent was removed under vacuum, and the title compound was purified by column chromatography, eluting with ethyl acetate, to obtain 360 g of ethyl 3-(2-pyridylamino)propionate as a white solid. Yield: 86.7%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09086390B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-2fb8517b37cf413eb1cfe529ce5a824c |
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| Source note | uspto-grants-2015_07 |
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