Methylamine → HCID 68283626, compound

Participants

Reaction Steps

To a solution of indole-1,3-dicarboxylic acid 3-benzyl ester 1-(4-nitro-phenyl)ester (45 mg, 0.108 mmol) in dry THF (1 mL) was added methylamine (2 M in THF, 270 μl, 0.54 mmol) and the reaction was stirred at RT for 15 min. The mixture was concentrated and the residue was taken up in Et2O and filtered to give the desired compound. TLC, Rf (c-hexane/EtOAc 1:1)=0.52; MS (LC/MS): 309.1 [M+H]+, 331.1 [M+Na]+, 639.2 [2M+Na]+, 353.2 [M+HCOO]−; tR (HPLC conditions a): 3.86 min.

Provenance & Evidence