HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-Carbamoyl-1H-indol-3-yl)-acetic acid → (1-Carbamoyl-5-fluoro-1H-indol-3-yl)-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-Carbamoyl-1H-indol-3-yl)-acetic acid | HCID 68283440 | — |
| Reactant | (1-carbamoyl-5-fluoro-1H-indol-3-yl)-acetic acid ethyl ester | HCID 68284150 | — |
| Product | (1-Carbamoyl-5-fluoro-1H-indol-3-yl)-acetic acid | HCID 68283615 | — |
Reaction Steps
was prepared in a similar manner as described in Scheme A8 Step B for (1-carbamoyl-1H-indol-3-yl)-acetic acid starting from (1-carbamoyl-5-fluoro-1H-indol-3-yl)-acetic acid ethyl ester. The crude product (yellowish solid) obtained after extractive work-up was used directly in the next step without purification. MS: 236.9 [M+H]+; tR (HPLC conditions b) 2.4 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085555B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-febffcbfb47c42c5aeda9d98a4956a5c |
| Source note | uspto-grants-2015_07 |