Methanol → (3-Carbamoyl-6-methoxy-indol-1-yl)-acetic acid

Participants

Reaction Steps

To a solution of (3-carbamoyl-6-methoxy-indol-1-yl)-acetic acid tert-butyl ester (300 mg, 0.99 mmol) in CH2Cl2 (9 mL) was added TFA (4.5 mL) at RT, and stirring was continued for 2 h. Methanol was then added to the reaction mixture, and volatiles were removed in vacuo. The residue was taken up in methanol and concentrated under reduced pressure to afford the title compound as a grey solid: MS: 249 [M+H]+, 497 [2M+H]+; tR (HPLC conditions c): 2.86 min. The material thus obtained was used in the next reaction step without further purification.

Provenance & Evidence