7-chloro-1H-indole-3-carbaldehyde → HCID 71009429, compound

HRID 1527214Notes

Reaction equation

HRID 1527214 reaction equation
[Cl:1]C1C=CC=C2C=1NC=C2C=O.[C:13]([C:16]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22](Cl)[CH:23]=2)[N:18]([CH2:26][C:27]([OH:29])=[O:28])[CH:17]=1)(=[O:15])[NH2:14]>>[C:13]([C:16]1[C:24]2[C:19](=[C:20]([Cl:1])[CH:21]=[CH:22][CH:23]=2)[N:18]([CH2:26][C:27]([OH:29])=[O:28])[CH:17]=1)(=[O:15])[NH2:14]

Participants

3

Reactant 2

HCID 6439587-chloro-1H-indole-3-carbaldehydeHCID 68283591HCID 68283591, compound

Product 1

HCID 71009429HCID 71009429, compound

Procedure

was prepared from 7-chloro-1H-indole-3-carbaldehyde [1008-07-7] using similar protocols as described in Scheme A11 for the preparation of (3-carbamoyl-5-chloro-indol-1-yl)-acetic acid. White solid. MS (LC/MS): 253 [M+H]+, 505 [2M+H]+; tR (HPLC conditions b): 3.32 min.

Workup

  1. custom3.32 min.

Sources & evidence

ORD record
ord-4e637870330846cd9aaf67b92924df26
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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