6-(benzyloxy)-1H-indole-3-carbaldehyde → (6-Benzyloxy-3-carbamoyl-indol-1-yl)-acetic acid

HRID 1527215Notes

Reaction equation

HRID 1527215 reaction equation
[CH2:1]([O:8]C1C=C2C(C(C=O)=CN2)=CC=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:20]([C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29](Cl)[CH:30]=2)[N:25]([CH2:33][C:34]([OH:36])=[O:35])[CH:24]=1)(=[O:22])[NH2:21]>>[CH2:1]([O:8][C:28]1[CH:27]=[C:26]2[C:31]([C:23]([C:20](=[O:22])[NH2:21])=[CH:24][N:25]2[CH2:33][C:34]([OH:36])=[O:35])=[CH:30][CH:29]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 220147916-(benzyloxy)-1H-indole-3-carbaldehydeHCID 68283591HCID 68283591, compound

Product 1

HCID 68283789(6-Benzyloxy-3-carbamoyl-indol-1-yl)-acetic acid

Procedure

was prepared from 6-benzyloxy-1H-indole-3-carbaldehyde [92855-64-6] using similar protocols as described in Scheme A11 for the preparation of (3-carbamoyl-5-chloro-indol-1-yl)-acetic acid. White solid. MS (LC/MS): 325 [M+H]+, 649 [2M+H]+; tR (HPLC conditions b): 4.06 min.

Workup

  1. custom4.06 min.

Sources & evidence

ORD record
ord-d0c61bebff2e40fca8f8eaf1fdae1890
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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