5-(phenylmethoxy)-1H-indole-3-carbaldehyde → (5-Benzyloxy-3-carbamoyl-indol-1-yl)-acetic acid

HRID 1527216Notes

Reaction equation

HRID 1527216 reaction equation
[CH2:1]([O:8]C1C=C2C(=CC=1)NC=C2C=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:20]([C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[C:29](Cl)[CH:30]=2)[N:25]([CH2:33][C:34]([OH:36])=[O:35])[CH:24]=1)(=[O:22])[NH2:21]>>[CH2:1]([O:8][C:29]1[CH:30]=[C:31]2[C:26](=[CH:27][CH:28]=1)[N:25]([CH2:33][C:34]([OH:36])=[O:35])[CH:24]=[C:23]2[C:20](=[O:22])[NH2:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 813985-(phenylmethoxy)-1H-indole-3-carbaldehydeHCID 68283591HCID 68283591, compound

Product 1

HCID 68283762(5-Benzyloxy-3-carbamoyl-indol-1-yl)-acetic acid

Procedure

was prepared from 5-benzyloxy-1H-indole-3-carbaldehyde [6953-22-6] using similar protocols as described in Scheme A11 for the preparation of (3-carbamoyl-5-chloro-indol-1-yl)-acetic acid. White solid. MS (LC/MS): 325 [M+H]+, 649 [2M+H]+; tR (HPLC conditions b): 4.04 min.

Workup

  1. custom4.04 min.

Sources & evidence

ORD record
ord-f5e02e950c604a9085bd8859de1feb58
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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