7-Methoxy-3-indolecarboxaldehyde → (3-Carbamoyl-7-methoxy-indol-1-yl)-acetic acid

HRID 1527217Notes

Reaction equation

HRID 1527217 reaction equation
[CH3:1][O:2]C1C=CC=C2C=1NC=C2C=O.[C:14]([C:17]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23](Cl)[CH:24]=2)[N:19]([CH2:27][C:28]([OH:30])=[O:29])[CH:18]=1)(=[O:16])[NH2:15]>>[C:14]([C:17]1[C:25]2[C:20](=[C:21]([O:2][CH3:1])[CH:22]=[CH:23][CH:24]=2)[N:19]([CH2:27][C:28]([OH:30])=[O:29])[CH:18]=1)(=[O:16])[NH2:15]

Participants

3

Reactant 2

HCID 41412187-Methoxy-3-indolecarboxaldehydeHCID 68283591HCID 68283591, compound

Product 1

HCID 68284295(3-Carbamoyl-7-methoxy-indol-1-yl)-acetic acid

Procedure

was prepared from 7-methoxy-1H-indole-3-carbaldehyde [109021-59-2] in a similar manner as described in Scheme A11 for the preparation of (3-carbamoyl-5-chloro-indol-1-yl)-acetic acid. White solid. MS (LC/MS): 249 [M+H]+, 497 [2M+H]+; tR (HPLC conditions c): 3.05 min.

Workup

  1. custom3.05 min.

Sources & evidence

ORD record
ord-b23f6c0486fc4975a5cec746e43eff07
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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