6-(Trifluoromethoxy)-1H-indole → (3-Carbamoyl-6-trifluoromethoxy-indol-1-yl)-acetic acid

HRID 1527219Notes

Reaction equation

HRID 1527219 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3]C1C=C2C(C=CN2)=CC=1.[C:15]([C:18]1[C:26]2[C:21](=[CH:22][C:23](F)=[C:24](F)[CH:25]=2)[N:20]([CH2:29][C:30]([OH:32])=[O:31])[CH:19]=1)(=[O:17])[NH2:16]>>[C:15]([C:18]1[C:26]2[C:21](=[CH:22][C:23]([O:3][C:2]([F:14])([F:13])[F:1])=[CH:24][CH:25]=2)[N:20]([CH2:29][C:30]([OH:32])=[O:31])[CH:19]=1)(=[O:17])[NH2:16]

Participants

3

Reactant 2

HCID 220489586-(Trifluoromethoxy)-1H-indoleHCID 68284024HCID 68284024, compound

Product 1

HCID 68284009(3-Carbamoyl-6-trifluoromethoxy-indol-1-yl)-acetic acid

Procedure

was prepared from 6-trifluoromethoxy-1H-indole [467451-91-8] in a similar manner as described for the preparation of (3-carbamoyl-5,6-difluoro-indol-1-yl)-acetic acid. White solid. MS (LC/MS): 303.0 [M+H]+, 605.0 [2M+H]+; tR (HPLC conditions k): 2.75 min.

Workup

  1. custom2.75 min.

Sources & evidence

ORD record
ord-e8df70ba27de4c1aaa9763f6e06899b1
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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