6-Bromo-5-fluoroindole → (6-Bromo-3-carbamoyl-5-fluoro-indol-1-yl)-acetic acid

HRID 1527220Notes

Reaction equation

HRID 1527220 reaction equation
[Br:1]C1C=C2C(C=CN2)=CC=1F.[C:12]([C:15]1[C:23]2[C:18](=[CH:19][C:20](F)=[C:21]([F:24])[CH:22]=2)[N:17]([CH2:26][C:27]([OH:29])=[O:28])[CH:16]=1)(=[O:14])[NH2:13]>>[Br:1][C:20]1[CH:19]=[C:18]2[C:23]([C:15]([C:12](=[O:14])[NH2:13])=[CH:16][N:17]2[CH2:26][C:27]([OH:29])=[O:28])=[CH:22][C:21]=1[F:24]

Participants

3

Reactant 2

HCID 222629226-Bromo-5-fluoroindoleHCID 68284024HCID 68284024, compound

Product 1

HCID 68283554(6-Bromo-3-carbamoyl-5-fluoro-indol-1-yl)-acetic acid

Procedure

was prepared from 6-bromo-5-fluoro-1H-indole [259860-08-7] in a similar manner as described for the preparation of (3-carbamoyl-5,6-difluoro-indol-1-yl)-acetic acid. White solid. MS (LC/MS): 315.0 [M+H]+, 631.0 [2M+H]+; tR (HPLC conditions k): 2.79 min.

Workup

  1. custom2.79 min.

Sources & evidence

ORD record
ord-53e89e85699840c0bed5777dccbd5154
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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