1-(6-Methoxy-1H-indol-3-yl)ethan-1-one → (3-Acetyl-6-methoxy-indol-1-yl)-acetic acid

HRID 1527228Notes

Reaction equation

HRID 1527228 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:12](=[O:14])[CH3:13])=[CH:8][NH:9]2)=[CH:5][CH:4]=1.C(C1C2C(=CC=C(OC(F)(F)F)C=2)N([CH2:32][C:33]([OH:35])=[O:34])C=1)(=O)C>>[C:12]([C:7]1[C:6]2[C:10](=[CH:11][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[N:9]([CH2:32][C:33]([OH:35])=[O:34])[CH:8]=1)(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 135741281-(6-Methoxy-1H-indol-3-yl)ethan-1-oneHCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid

Product 1

HCID 68284145(3-Acetyl-6-methoxy-indol-1-yl)-acetic acid

Procedure

was prepared from 1-(6-methoxy-1H-indol-3-yl)-ethanone [99532-52-2] in a similar manner as described in step B and C of Scheme A13 for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid. Brown solid. MS: 248 [M+H]+, 517 [2M+Na]+; tR (HPLC conditions k): 2.30 min.

Workup

  1. custom2.30 min.

Sources & evidence

ORD record
ord-04a7c19c44224c518ece3edc60ad294b
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

Loading…