1H-indole-6-carbonitrile → (3-Acetyl-6-cyano-indol-1-yl)-acetic acid

HRID 1527230Notes

Reaction equation

HRID 1527230 reaction equation
[NH:1]1C2C(=CC=C(C#N)C=2)C=[CH:2]1.[C:12]([C:15]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21](OC(F)(F)F)[CH:22]=2)[N:17]([CH2:29][C:30]([OH:32])=[O:31])[CH:16]=1)(=[O:14])[CH3:13]>>[C:12]([C:15]1[C:23]2[C:18](=[CH:19][C:20]([C:2]#[N:1])=[CH:21][CH:22]=2)[N:17]([CH2:29][C:30]([OH:32])=[O:31])[CH:16]=1)(=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 851461H-indole-6-carbonitrileHCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid

Product 1

HCID 68283820(3-Acetyl-6-cyano-indol-1-yl)-acetic acid

Procedure

was prepared from 1H-indole-6-carbonitrile in a similar manner as described in Scheme A13 for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid. MS: 243 [M+H]+; tR (HPLC conditions k): 2.72 min.

Workup

  1. custom2.72 min.

Sources & evidence

ORD record
ord-18e8b8e6822b40b684666ba9f91762f5
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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