6-(benzyloxy)-1H-indole → (3-Acetyl-6-benzyloxy-indol-1-yl)-acetic acid

HRID 1527232Notes

Reaction equation

HRID 1527232 reaction equation
[CH2:1]([O:8]C1C=C2C(C=CN2)=CC=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:18]([C:21]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27](OC(F)(F)F)[CH:28]=2)[N:23]([CH2:35][C:36]([OH:38])=[O:37])[CH:22]=1)(=[O:20])[CH3:19]>>[C:18]([C:21]1[C:29]2[C:24](=[CH:25][C:26]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:27][CH:28]=2)[N:23]([CH2:35][C:36]([OH:38])=[O:37])[CH:22]=1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 2608046-(benzyloxy)-1H-indoleHCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid

Product 1

HCID 68284220(3-Acetyl-6-benzyloxy-indol-1-yl)-acetic acid

Procedure

was prepared from 6-benzyloxy-1H-indole in a similar manner as described in Scheme A13 for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid. MS: 324 [M+H]+, 647 [2M+1]+; tR (HPLC conditions k): 3.38 min.

Workup

  1. custom3.38 min.

Sources & evidence

ORD record
ord-d1614a5c8179430990e2f7819be1bc52
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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