HCID 13574130, compound → HCID 68283580, compound

HRID 1527235Notes

Reaction equation

HRID 1527235 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]([C:14](=[O:16])[CH3:15])=[CH:10][NH:11]2)=[CH:7][CH:6]=1)=[O:4].C(C1C2C(=CC=C(OC(F)(F)F)C=2)N([CH2:34][C:35]([OH:37])=[O:36])C=1)(=O)C>>[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]([C:14](=[O:16])[CH3:15])=[CH:10][N:11]2[CH2:34][C:35]([OH:37])=[O:36])=[CH:7][CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 13574130HCID 13574130, compoundHCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid

Product 1

HCID 68283580HCID 68283580, compound

Procedure

was prepared from 3-acetyl-1H-indole-6-carboxylic acid methyl ester [106896-61-1] in a similar manner as described in step B and C of Scheme A13 for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid. Colored solid. MS: 276 [M+H]+; tR (HPLC conditions k): 2.80 min.

Workup

  1. custom2.80 min.

Sources & evidence

ORD record
ord-6ed7e7d3fd7147f3bd8ef9a4244a390b
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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