Ethanone, 2-hydroxy-1-(1H-indol-3-yl)- → HCID 68284897, compound

HRID 1527241Notes

Reaction equation

HRID 1527241 reaction equation
[OH:1][CH2:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)=[O:4].C(C1C2C(=CC=C(OC(F)(F)F)C=2)N([CH2:31][C:32]([OH:34])=[O:33])C=1)(=O)C>>[OH:1][CH2:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:7]([CH2:31][C:32]([OH:34])=[O:33])[CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 200631Ethanone, 2-hydroxy-1-(1H-indol-3-yl)-HCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid

Product 1

HCID 68284897HCID 68284897, compound

Procedure

was prepared from 2-hydroxy-1-(1H-indol-3-yl)-ethanone [2400-51-3] in a similar manner as described in Scheme A13 (step B and C) for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid. Colored solid. MS: 234.0 [M+H]+, 489.0 [2M+Na]+; tR (HPLC conditions c): 3.11 min.

Workup

  1. custom3.11 min.

Sources & evidence

ORD record
ord-bd538968a54f4310981c40654e834ad6
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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