(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid → HCID 68283748, compound

HRID 1527246Notes

Reaction equation

HRID 1527246 reaction equation
[CH:1]([Si:4]([CH:19]([CH3:21])[CH3:20])([CH:16]([CH3:18])[CH3:17])[O:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[CH:10]2)([CH3:3])[CH3:2].[C:22](C1C2C(=CC=C(OC(F)(F)F)C=2)N(CC(O)=O)C=1)(=[O:24])[CH3:23]>>[CH:19]([Si:4]([CH:1]([CH3:3])[CH3:2])([CH:16]([CH3:18])[CH3:17])[O:5][CH2:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[C:10]2[C:22](=[O:24])[CH3:23])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acidHCID 71009214HCID 71009214, compound

Product 1

HCID 68283748HCID 68283748, compound

Procedure

The title compound was prepared from 5-triisopropylsilanyloxymethyl-1H-indole in a similar manner as described in step A of Scheme A13 for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid. Brown solid. MS: 346 [M+H]+; tR (HPLC conditions c): 6.86 min.

Workup

  1. custom6.86 min.

Sources & evidence

ORD record
ord-cdf12853b14b45149408e68c478d944d
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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