1H-pyrrolo[2,3-b]pyridine-6-carbonitrile → HCID 71009231, compound

HRID 1527251Notes

Reaction equation

HRID 1527251 reaction equation
[C:1]([C:4]1[C:12]2[C:7](=[N:8][C:9](OC)=[CH:10][CH:11]=2)[N:6]([CH2:15][C:16]([OH:18])=[O:17])[CH:5]=1)(=[O:3])[CH3:2].[NH:19]1C2=NC(C#N)=CC=C2C=[CH:20]1>>[C:1]([C:4]1[C:12]2[C:7](=[N:8][C:9]([C:20]#[N:19])=[CH:10][CH:11]=2)[N:6]([CH2:15][C:16]([OH:18])=[O:17])[CH:5]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 105347761H-pyrrolo[2,3-b]pyridine-6-carbonitrileHCID 68284171HCID 68284171, compound

Product 1

HCID 71009231HCID 71009231, compound

Procedure

was prepared using similar procedures as described for the synthesis of (3-acetyl-6-methoxy-pyrrolo[2,3-b]pyridin-1-yl)-acetic acid in Scheme A15 from 1H-pyrrolo[2,3-b]pyridine-6-carbonitrile. MS (UPLC/MS): 244.1 [M+H]+, 242.1 [M−H]−; tR (HPLC conditions f): 1.42 min.

Workup

  1. customwas prepared
  2. custom1.42 min.

Sources & evidence

ORD record
ord-5025daa10fb14a5eb25b1cf20fef871e
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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