Sodium Hydroxide → HCID 178421791, compound

HRID 1527269Notes

Reaction equation

HRID 1527269 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[CH:10]=[N:9][NH:8][C:5]2=[CH:6][N:7]=1.[Br:11]Br.[OH-].[Na+]>O>[Br:11][C:10]1[C:4]2[C:5](=[CH:6][N:7]=[C:2]([CH3:1])[CH:3]=2)[NH:8][N:9]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24408BromineHCID 126684875-methyl-1H-pyrazolo[3,4-c]pyridine

Product 1

HCID 178421791HCID 178421791, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-Methyl-1H-pyrazolo[3,4-c]pyridine (2 g, 15.02 mmol) and bromine (0.774 mL, 15.02 mmol) in water (71.5 mL) were stirred at RT for 1 h. The reaction mixture was neutralized with NaOH (20% in water), the precipitate was filtered, washed with water and dried under high vacuum. Yellow powder, MS (UPLC/MS): 212/214 [M+H]+, 210/212 [M−H]−; tR (HPLC conditions f): 0.74 min.

Workup

  1. filtrationthe precipitate was filtered
  2. washwashed with water
  3. customdried under high vacuum
  4. custom0.74 min.

Sources & evidence

ORD record
ord-acd6d83026ff4a27b12bbf0281622fea
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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