tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate → 2-(3-Acetyl-1H-indazol-1-yl)acetic acid

HRID 1527275Notes

Reaction equation

HRID 1527275 reaction equation
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[N:5]=1)(=[O:3])[CH3:2].C(C1C2C(=CC=C(OC(F)(F)F)C=2)N(CC(O)=O)C=1)(=O)C>>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 68283733tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetateHCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid

Product 1

HCID 682847152-(3-Acetyl-1H-indazol-1-yl)acetic acid

Procedure

The title compound was prepared from tert-butyl 2-(3-acetyl-1H-indazol-1-yl)acetate in a similar manner as described in step C of Scheme A13 for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid. MS: 219 [M+H]+; tR (HPLC conditions k): 2.78 min.

Workup

  1. custom2.78 min.

Sources & evidence

ORD record
ord-4f2d0d8b79c846648317e94013c25ab0
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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