HCID 68283593, compound → HCID 68283045, compound

HRID 1527280Notes

Reaction equation

HRID 1527280 reaction equation
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]([CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])[N:5]=1)(=[O:3])[CH3:2].C(C1C2C(=CC=C(OC(F)(F)F)C=2)N(CC(O)=O)C=1)(=O)C>>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[N:6]([CH2:17][C:18]([OH:20])=[O:19])[N:5]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 68283593HCID 68283593, compoundHCID 68284505(3-Acetyl-5-trifluoromethoxy-indol-1-yl)acetic acid

Product 1

HCID 68283045HCID 68283045, compound

Procedure

The title compound was prepared from tert-butyl 2-(3-acetyl-5,6-dimethoxy-1H-indazol-1-yl)acetate in a similar manner as described in step C of Scheme A13 for the preparation of (3-acetyl-5-trifluoromethoxy-indol-1-yl)-acetic acid. MS: 279 [M+H]+; tR (HPLC conditions k): 2.73 min.

Workup

  1. custom2.73 min.

Sources & evidence

ORD record
ord-1500490af1a04404a15be02bd1502482
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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