1H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)- → (3-Carbamoyl-5-cyclopropyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetic acid

HRID 1527299Notes

Reaction equation

HRID 1527299 reaction equation
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2].[CH:17]1(C2C=C3C=NNC3=CN=2)[CH2:19][CH2:18]1>>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[C:10]([CH:17]3[CH2:19][CH2:18]3)[CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

Participants

3

Reactant 2

HCID 682831141H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)-HCID 682844125-cyclopropyl-1H-pyrazolo[3,4-c]pyridine

Product 1

HCID 71009433(3-Carbamoyl-5-cyclopropyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetic acid

Procedure

was prepared by using the same procedure as described for the preparation of 2-(3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetic acid and by starting from 5-cyclopropyl-1H-pyrazolo[3,4-c]pyridine (Scheme A26). MS (LC-MS): 261 [M+H]+, tR (HPLC conditions c): 1.84 min.

Workup

  1. customwas prepared
  2. custom1.84 min.

Sources & evidence

ORD record
ord-ea85e1fa88414f15b423b3b8ea6468dc
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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