反应详情

A solution of 6-cyclopropyl-4-methylpyridin-3-amine (130 mg, 0.88 mmol) in AcOH (10 mL) was treated with a solution of sodium nitrite (61 mg, 0.88 mmol) in water (0.5 mL). The reaction mixture was stirred at RT for 15 min and then was allowed to stand at RT for 24 h. AcOH was evaporated under reduced pressure and the residual aqueous solution was partitioned between EtOAc and sat. aq. NaHCO3. The organic solution was washed with water and brine, then dried (Phase separator) and concentrated under. MS (LC-MS): 160 [M+H]+, tR (HPLC conditions c): 2.07 min.

1. waitto stand at RT for 24 h
2. customAcOH was evaporated under reduced pressure
3. customthe residual aqueous solution was partitioned between EtOAc and sat. aq. NaHCO3
4. washThe organic solution was washed with water and brine
5. customdried (Phase separator)
6. concentrationconcentrated under
7. custom2.07 min.