1H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)- → (3-Carbamoyl-5-(trifluoromethyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)acetic acid

HRID 1527303Notes

Reaction equation

HRID 1527303 reaction equation
[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[CH:10][CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2].[F:17][C:18]([F:29])([F:28])C1C=C2C=NNC2=CN=1>>[C:1]([C:4]1[C:12]2[C:7](=[CH:8][N:9]=[C:10]([C:18]([F:29])([F:28])[F:17])[CH:11]=2)[N:6]([CH2:13][C:14]([OH:16])=[O:15])[N:5]=1)(=[O:3])[NH2:2]

Participants

3

Reactant 2

HCID 682831141H-Pyrazolo[3,4-c]pyridine-1-acetic acid, 3-(aminocarbonyl)-HCID 682833945-(Trifluoromethyl)-1H-pyrazolo[3,4-C]pyridine

Product 1

HCID 71009650(3-Carbamoyl-5-(trifluoromethyl)-1H-pyrazolo[3,4-c]pyridin-1-yl)acetic acid

Procedure

was prepared by using the same procedure as described for the preparation of 2-(3-carbamoyl-1H-pyrazolo[3,4-c]pyridin-1-yl)acetic acid and by starting from 5-trifluoromethyl-1H-pyrazolo[3,4-c]pyridine (Scheme A26). MS (LC-MS): 289 [M+H]+, tR (HPLC conditions c): 2.93 min.

Workup

  1. customwas prepared
  2. custom2.93 min.

Sources & evidence

ORD record
ord-320207db7e0c4d50bf86f7d17a48cd1f
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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