1H-pyrazolo(3,4-b)pyridine → (3-Carbamoyl-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid

HRID 1527309Notes

Reaction equation

HRID 1527309 reaction equation
[NH:1]1C2=NC=CC=C2C=N1.[C:10]([C:13]1[C:21]2[C:16](=CN=[C:19]([CH3:22])[CH:20]=2)[N:15]([CH2:23][C:24]([OH:26])=[O:25])[N:14]=1)(=[O:12])[NH2:11]>>[C:10]([C:13]1[C:21]2[C:16](=[N:1][CH:22]=[CH:19][CH:20]=2)[N:15]([CH2:23][C:24]([OH:26])=[O:25])[N:14]=1)(=[O:12])[NH2:11]

Participants

3

Reactant 2

HCID 27558501H-pyrazolo(3,4-b)pyridineHCID 68283471HCID 68283471, compound

Product 1

HCID 71009624(3-Carbamoyl-pyrazolo[3,4-b]pyridin-1-yl)-acetic acid

Procedure

was prepared from 1H-pyrazolo[3,4-b]pyridine [271-73-8] by using the same procedures as described for the preparation of (3-carbamoyl-5-methyl-pyrazolo[3,4-c]pyridin-1-yl)-acetic acid (Scheme A27). MS (LC-MS): 221 [M+H]+, tR (HPLC conditions k): 0.87 min.

Workup

  1. custom0.87 min.

Sources & evidence

ORD record
ord-54d2a5b8d09a4e8a9cb61ef5e7438912
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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