反应详情

A solution of (2R,3R)-3-fluoro-pyrrolidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester (70.0 mg, 0.216 mmol) in MeOH (10 mL) was hydrogenated at RT (1 atm) over Pd/C 10% (35 mg, 50% w/w) for 48 h. The reaction mixture was filtered through a 0.45 microns filter and concentrated under reduced pressure to give the crude title compound (>95% purity by 1H-NMR) as a white solid. MS (LC/MS): 232 [M−H]+; tR (HPLC conditions b): 2.26 min. This material was used in the next reaction step without further purification.

1. customwas hydrogenated at RT
2. customfor 48 h
3. filtrationThe reaction mixture was filtered through a 0.45 microns
4. filtrationfilter
5. concentrationconcentrated under reduced pressure