HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → (2S,5R)-1-Benzyl-5-(ethoxycarbonyl)pyrrolidine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | (2S,5R)-Diethyl 1-benzylpyrrolidine-2,5-dicarboxylate | HCID 6932547 | — |
| Product | (2S,5R)-1-Benzyl-5-(ethoxycarbonyl)pyrrolidine-2-carboxylic acid | HCID 68283039 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Gazzetta Chimica Italiana, 1996, 126, 543-554 from (2R,5S)-1-benzyl-pyrrolidine-2,5-dicarboxylic acid diethyl ester prepared from benzylamine and diethyl meso-dibromoadipate according to the procedure described in J. Med. Chem. 2006, 49, 11, 3068-3076.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085555B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-1b281f1bbcb348a2807231916d8a7038 |
| Source note | uspto-grants-2015_07 |