HuagongsheHuagongshe Chemistry Print Report · For research reference only
[3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol → 3-Fluoro-2-(trifluoromethyl)pyridine-4-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [3-Fluoro-2-(trifluoromethyl)pyridin-4-yl]methanol | HCID 68283421 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Fluoro-2-(trifluoromethyl)pyridine-4-carbaldehyde | HCID 86673864 | — |
Reaction Steps
A mixture of (3-fluoro-2-trifluoromethyl-pyridin-4-yl)-methanol (0.620 g, 3.18 mmol) and activated MnO2 (3.20 g, 36.5 mmol) in CH2Cl2 was stirred at RT overnight. The solid was filtered off, washed with CH2Cl2, and the filtrate was concentrated under mildly reduced pressure to afford the title compound as a yellow liquid. MS (LC/MS): 212.0 [M+NH4]+, 226.0 [M+MeOH]+. tR (HPLC conditions c): 3.26 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085555B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-8b86983cf75a440fb942803377df3f4b |
| Source note | uspto-grants-2015_07 |