HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Ethanediamine, N1,N1,N2-trimethyl- → {3-Chloro-5-[(2-dimethylamino-ethyl)-methyl-amino]-2-fluoro-benzyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Ethanediamine, N1,N1,N2-trimethyl- | HCID 67338 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | Carbamic acid, N-[(5-bromo-3-chloro-2-fluorophenyl)methyl]-, 1,1-dimethylethyl ester | HCID 68283623 | — |
| Product | {3-Chloro-5-[(2-dimethylamino-ethyl)-methyl-amino]-2-fluoro-benzyl}-carbamic acid tert-butyl ester | HCID 68283334 | — |
Reaction Steps
was prepared according to Scheme C1 (step A) from (5-bromo-3-chloro-2-fluoro-benzyl)-carbamic acid tert-butyl ester (300 mg, 0.89 mmol), N,N,N′-trimethyl-ethylenediamine (136 mg, 1.3 mmol), sodium tert-butoxide (170 mg, 1.8 mmol) and di-μ-bromobis(tri-tert-butylphosphino)dipalladium (I) [CAS 185812-86-6] (34 mg, 0.04 mmol). MS (LC-MS): 360.3 [M]+; tR (HPLC conditions c): 4.15 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09085555B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-24fed91ddfd44a2ab08bd84a38281e64 |
| Source note | uspto-grants-2015_07 |