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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1527495Generated: November 4, 2026

Hydrochloric Acid → 3-Chloro-2-fluoro-5-(4-methoxy-piperidin-1-ylmethyl)-benzylamine

https://huagongshe.com/reaction/1527495

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant[3-Chloro-2-fluoro-5-(4-methoxy-piperidin-1-ylmethyl)-benzyl]-carbamic acid tert-butyl esterHCID 68282992—
Solvent1,4-DioxaneHCID 31275—
Product3-Chloro-2-fluoro-5-(4-methoxy-piperidin-1-ylmethyl)-benzylamineHCID 71009612—

Reaction Steps

was prepared according to Scheme C2 (step D) from [3-chloro-2-fluoro-5-(4-methoxy-piperidin-1-ylmethyl)-benzyl]-carbamic acid tert-butyl ester (225 mg, 0.61 mmol) and 4N HCl in dioxane. MS (LC-MS): 287.0 [M]+; tR (HPLC conditions c): 2.34 min.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09085555B2
Source datasetuspto-grants-2015_07
ORD IDord-68cefc90ac1d4467a48c32c399556c18
Source noteuspto-grants-2015_07