1H-Pyrrolo[2,3-c]pyridine-1-acetic acid, 3-acetyl- → HCID 71037723, compound

HRID 1527520Notes

Reaction equation

HRID 1527520 reaction equation
C(C1C2[C:7](=CN=CC=2)[N:6](CC(O)=O)[CH:5]=1)(=O)C.[NH2:17][C@@H:18]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:23]=1[F:29])[CH2:19][CH2:20]O>>[Cl:28][C:24]1[C:23]([F:29])=[C:22]([C@H:18]([NH2:17])[CH2:19][CH2:20][N:6]([CH3:7])[CH3:5])[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 682831851H-Pyrrolo[2,3-c]pyridine-1-acetic acid, 3-acetyl-HCID 68283895HCID 68283895, compound

Product 1

HCID 71037723HCID 71037723, compound

Procedure

was prepared using similar procedures as described for the synthesis of (3-acetyl-pyrrolo[2,3-c]pyridin-1-yl)-acetic acid in Scheme C4 from (R)-3-amino-3-(3-chloro-2-fluoro-phenyl)-propan-1-ol. 1H-NMR (400 MHz, DMSO): δ (ppm): 8.89 (m, 2H), 7.73 (m, 2H), 7.39 (t, 1H), 4.69 (m, 1H), 3.13 (m, 1H), 2.98 (m, 1H), 2.73 (s, 6H), 2.47 (m, 1H), 2.34 (1H).

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-eb08856953e54a77a18ce157dcc33bf9
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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