2-Bromo-3-fluoropyridine → HCID 68283903, compound

HRID 1527528Notes

Reaction equation

HRID 1527528 reaction equation
Cl[C:2]1[C:3]([C:8]2[C:9]([F:15])=[C:10]([NH2:14])[CH:11]=[CH:12][CH:13]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.BrC1C([F:23])=CC=CN=1.FC1C([N+]([O-])=O)=CC=CC=1B(O)O>>[F:15][C:9]1[C:8]([C:3]2[C:2]([F:23])=[CH:7][CH:6]=[CH:5][N:4]=2)=[CH:13][CH:12]=[CH:11][C:10]=1[NH2:14]

Participants

4

Reactant 3

HCID 27628032-Bromo-3-fluoropyridineHCID 46738914(2-Fluoro-3-nitrophenyl)boronic acidHCID 68283569HCID 68283569, compound

Product 1

HCID 68283903HCID 68283903, compound

Procedure

was prepared by using the same procedures as described for the preparation of 3-(3-chloro-pyridin-2-yl)-2-fluoro-phenylamine in Scheme C6, starting from 2-bromo-3-fluoropyridine [40273-45-8] and 2-fluoro-3-nitrophenylboronic acid [1150114-29-6]. MS (LC-MS): 207 [M+H]+; tR (HPLC conditions k): 2.39 min.

Workup

  1. customwas prepared
  2. custom2.39 min.

Sources & evidence

ORD record
ord-1a0901dc817d417687bc498c7ac3c221
Source dataset
uspto-grants-2015_07
Patent number
US09085555B2

Reaction notes

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