Trifluoroacetic acid → HCID 68284621, compound

Participants

Reaction Steps

To (1-carbamoyl-3-{[(1R,3S,5R)-3-(2-fluoro-benzylcarbamoyl)-2-aza-bicyclo[3.1.0]hexane-2-carbonyl]-amino}-1H-indol-5-yloxy)-acetic acid tert-butyl ester Example 390 (18 mg, 0.032 mmol) in CH2Cl2 (0.5 mL) was added TFA (97 μL, 1.27 mmol) and the mixture was stirred at RT overnight. Then concentrated, taken up in CH2Cl2 and filtered-off to give the desired material which was further dried under high vacuum. MS (LC-MS): 510.1 [M+H]+, 532.2 [M+Na]+, 508.1 [M−H]−, 465.1 [M−CONH2]−; tR (HPLC conditions f): 1.52 min.

Provenance & Evidence