HCID 57519820, compound → HCID 68284106, compound

HRID 1527582Notes

Reaction equation

C(C1C2C(=CC=CC=2)N(CC(N2C[C@H](F)C[C@H]2C(NCC2C=C(C=C(Cl)C=2F)C(O)=O)=O)=O)C=1)(=O)C.C[O:38][C:39](=[O:73])[C:40]1[CH:45]=[C:44]([Cl:46])[C:43]([F:47])=[C:42]([CH2:48][NH:49][C:50]([C@@H:52]2[CH2:57][C@@H:56]3[C@@H:54]([CH2:55]3)[N:53]2[C:58](=[O:72])[CH2:59][N:60]2[C:68]3[C:63](=[CH:64][CH:65]=[CH:66][CH:67]=3)[C:62]([C:69](=[O:71])[CH3:70])=[CH:61]2)=[O:51])[CH:41]=1>>[C:69]([C:62]1[C:63]2[C:68](=[CH:67][CH:66]=[CH:65][CH:64]=2)[N:60]([CH2:59][C:58]([N:53]2[C@H:52]([C:50]([NH:49][CH2:48][C:42]3[CH:41]=[C:40]([CH:45]=[C:44]([Cl:46])[C:43]=3[F:47])[C:39]([OH:73])=[O:38])=[O:51])[CH2:57][C@@H:56]3[C@H:54]2[CH2:55]3)=[O:72])[CH:61]=1)(=[O:71])[CH3:70]

Participants

Reactant 2

HCID 57519820HCID 57519820, compound

HCID 68283607HCID 68283607, compound

Product 1

HCID 68284106HCID 68284106, compound

Procedure

The title compound was prepared according to procedure described for the preparation of 3-[({(2S,4R)-1-[2-(3-acetyl-indol-1-yl)-acetyl]-4-fluoro-pyrrolidine-2-carbonyl}-amino)-methyl]-5-chloro-4-fluoro-benzoic acid Example 605 starting from 3-[({(1R,3S,5R)-2-[2-(3-acetyl-indol-1-yl)-acetyl]-2-aza-bicyclo[3.1.0]hexane-3-carbonyl}-amino)-methyl]-5-chloro-4-fluoro-benzoic acid methyl ester Example 480. MS: 512.0 [M+H]+; tR (HPLC conditions c): 4.41 min.

Workup

custom4.41 min.

Sources & evidence

ORD record: ord-8e6c0b31f43e4ff2a8d4ad6f8d1ddbcf
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09085555B2

Reaction notes

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