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HRID1527585

反应详情

EQUATION

反应方程式

HRID 1527585 的结构方程式

REACTANTS

反应物

3
结构：CC(=O)c1cn(CC(=O)N2[C@H](C(=O)NCc3cccc(Cl)c3F)C[C@@]3(CO)C[C@@H]23)c2ncccc12
HCID68283700

未命名化合物

结构：CC(C)(C)OC(=O)N1[C@@H]2C[C@@H]2C[C@H]1C(=O)N[C@H](CO)c1cccc(Cl)c1F
HCID68283751

未命名化合物

结构：CCOC(C)=O.ClCl
HCID86673875

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)c1cn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)N[C@H](CO)c2cccc(Cl)c2F)c2ncccc12
HCID86673874

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in 2 steps according to the procedure described for the preparation of Example 610 (1R,3S,5S)-2-[2-(3-acetyl-pyrrolo[2,3-b]pyridin-1-yl)-acetyl]-5-hydroxymethyl-2-aza-bicyclo[3.1.0]hexane-3-carboxylic acid 3-chloro-2-fluoro-benzylamide from (1R,3S,5R)-3-[(S)-1-(3-chloro-2-fluoro-phenyl)-2-hydroxy-ethylcarbamoyl]-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester (prepared as described in Scheme B9). White powder. TLC, Rf (CH2/Cl2/EtOAc 9:1)=0.70; MS (UPLC/MS): 499.3/501.3 [M+H]+, 543.2/545.3 [M+HCOO]−; tR (HPLC conditions a): 3.02 min.

WORKUP

后处理

  1. custom3.02 min.