HRID1527607

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(OC(F)(F)F)c2F)c2ccc(OCc3ccccc3)cc12

HCID68283070

未命名化合物

PRODUCTS

生成物

结构：CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(OC(F)(F)F)c2F)c2ccc(O)cc12

HCID68283143

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A mixture of (1R,3S,5R)-2-[2-(3-acetyl-5-benzyloxy-indazol-1-yl)-acetyl]-2-aza-bicyclo[3.1.0]hexane-3-carboxylic acid (2-fluoro-3-trifluoromethoxy-phenyl)-amide (2.0 g, 3.28 mmol) and Pd/C (10%, 165 mg) in MeOH (40 mL) was stirred under a H2 atmosphere for 1 h. The mixture was filtered through a celite pad and concentrated. The product was used in the next step without further purification. MS (UPLC-MS): 521 [M+H]+; tR (HPLC conditions f): 2.02 min.

WORKUP

后处理

filtrationThe mixture was filtered through a celite pad
concentrationconcentrated
customThe product was used in the next step without further purification
custom2.02 min.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2aa63269d59f4b55a598939dc3a9a72e
来源数据集: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09085555B2
来源说明: uspto-grants-2015_07

反应 SMILES

[F:1][C:2]1[C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:5]=[CH:4][C:3]=1[NH:13][C:14]([C@@H:16]1[CH2:21][C@@H:20]2[C@@H:18]([CH2:19]2)[N:17]1[C:22](=[O:44])[CH2:23][N:24]1[C:32]2[C:27](=[CH:28][C:29]([O:33]CC3C=CC=CC=3)=[CH:30][CH:31]=2)[C:26]([C:41](=[O:43])[CH3:42])=[N:25]1)=[O:15]>CO.[Pd]>[F:1][C:2]1[C:7]([O:8][C:9]([F:12])([F:11])[F:10])=[CH:6][CH:5]=[CH:4][C:3]=1[NH:13][C:14]([C@@H:16]1[CH2:21][C@@H:20]2[C@@H:18]([CH2:19]2)[N:17]1[C:22](=[O:44])[CH2:23][N:24]1[C:32]2[C:27](=[CH:28][C:29]([OH:33])=[CH:30][CH:31]=2)[C:26]([C:41](=[O:43])[CH3:42])=[N:25]1)=[O:15]