(E)-3-(6-methyl-2,3,4,5-tetramethoxyphenyl)-2-nonylpropenoic acid → APE1/Ref-1 Redox Inhibitor APX3330

Participants

Reaction Steps

Compound 1 was prepared from 9f (1.13 g, 2.77 mmol) as described above for 10a using Method A to give 0.443 g (1.17 mmol, 42%) of the product as a red solid following flash chromatography (2:3 Et2O:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes.

Provenance & Evidence